HIV Rev response element - definição. O que é HIV Rev response element. Significado, conceito
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O que (quem) é HIV Rev response element - definição


HIV Rev response element         
  • '''RRE Secondary Structure.''' Secondary Structure of the minimal functional RRE (~250 nt). The RRE contains several stem loops, the most well characterized being the high affinity binding site, IIB. IIB is necessary but not sufficient for RRE mediated export. Stem IA is a more recently identified, secondary binding site. The remaining binding sites on the RRE have not been characterized yet.
  • '''RRE Location in the HIV-1 Genome.''' RRE is located within the Env coding region of HIV-1.
  • '''Rev-ARM/IIB structure.''' (Left) Stem IIB RNA(red) A-‐form major groove cradling the Rev-‐ARM α-‐helix (blue). The Rev-ARM is a short peptide that represents the RNA binding domain of Rev. (Right) A rotated view showing the purine-‐purine base pairs (yellow) that widen the RNA major groove.
  • '''HIV-1 RNA export.''' In the early phase (top), transcribed viral RNAs (9kb) are spliced down to 2kb before export. One of these 2kb messages is translated to produce Rev which is then imported into the nucleus. In the late phase (bottom), Rev binds the RRE of newly transcribed RNAs before splicing and exports the unspliced (9kb) and partially spliced (4kb) messages to the cytoplasm. Translation of these messages produces late stage viral proteins. 9 kb messages can also serve as genomes for new virions.
  • '''Jellyfish model of Rev/RRE assembly.''' This is a schematic representation of how an export-competent Rev–RRE complex might form: Rev molecules assemble onto the RRE scaffold to form an oligomeric assembly. In the “jellyfish” model, the jellyfish head comprises Rev oligomers and RRE; the Rev–NESs form the "tentacles" that interact with Crm1 (shown in the space-filled model) making the complex ready for export.
The HIV-1 Rev response element (RRE) is a highly structured, ~350 nucleotide RNA segment present in the Env coding region of unspliced and partially spliced viral mRNAs. In the presence of the HIV-1 accessory protein Rev, HIV-1 mRNAs that contain the RRE can be exported from the nucleus to the cytoplasm for downstream events such as translation and virion packaging.
Hormone response element         
NUCLEOTIDE SEQUENCES RECOGNIZED BY SPECIFIC REGULATORY TRANSCRIPTION FACTORS
Hormone responsive element; Hormone response element; Response elements; DNA responsive element; Estrogen response element; Estrogen regulatory element; Glucocorticoid response elements; Glucocorticoid response element; Androgen response element; Estrogen response elements
A hormone response element (HRE) is a short sequence of DNA within the promoter of a gene, that is able to bind to a specific hormone receptor complex and therefore regulate transcription. The sequence is most commonly a pair of inverted repeats separated by three nucleotides, which also indicates that the receptor binds as a dimer.
Response element         
NUCLEOTIDE SEQUENCES RECOGNIZED BY SPECIFIC REGULATORY TRANSCRIPTION FACTORS
Hormone responsive element; Hormone response element; Response elements; DNA responsive element; Estrogen response element; Estrogen regulatory element; Glucocorticoid response elements; Glucocorticoid response element; Androgen response element; Estrogen response elements
Response elements are short sequences of DNA within a gene promoter or enhancer region that are able to bind specific transcription factors and regulate transcription of genes.